This is a mechanism-based study in healthy adults to determine the effect of the CYP2C9 M1L
gene polymorphism on the functional activity of the encoded CYP2C9 enzyme towards the probe
substrate naproxen. CYP2C9 activity will be evaluated by measurement of O-desmethyl naproxen
and unchanged naproxen in 24-hour urine following administration of a single oral dose of
naproxen (Aleve) in Yup'ik Alaska Native adult men and women who were previously determined
in a separate observational study to be homozygous for the CYP2C9*1 allele or a carrier of
the CYP2C9 M1L allele.
Phase:
Phase 4
Details
Lead Sponsor:
University of Washington
Collaborators:
National Institute of General Medical Sciences (NIGMS) Oregon Health and Science University