Nasal Allergen Challenge - Reproducibility of Biomarkers and Effect of Topical Steroid Treatment

• Status: Unknown status
• Trial end date: 2019-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Subjects with allergic asthma developing the required nasal symptoms in response to nasal allergen titration during a screening period will be randomized 1:1 to one of 2 cohorts. All subjects will have repeated nasal challenges with allergen. One cohort will have nasal saline challenge as control. One cohort will have intranasal corticosteroid intervention.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Gail Gauvreau
• Treatments: Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide

Criteria

Inclusion Criteria:

• allergic rhinitis + mild asthma

Exclusion Criteria:

• other respiratory disease

• any medication for treatment of asthma/allergic rhinitis with the exception of infrequent beta-2 agonist.