This study will investigate how well OC-01 (varenicline) nasal spray can treat the signs and
symptoms of dry eye disease in those Sjogren's Syndrome. Patients at least 18 years old with
moderate-to-severe Sjogren's dry eye disease may be eligible for this study. If you are
eligible to participate in the study and you decide to join, there will be 3 study visits
over approximately 1 month. You will also self-administer the nasal spray at home every day,
2 times a day during this month.