Nasal Versus Venous Lorazepam for Control of Acute Seizures in Children
Status:
Completed
Trial end date:
2009-04-01
Target enrollment:
Participant gender:
Summary
Status epilepticus (SE) is a common pediatric emergency which is potentially life-threatening
and requires rapid termination. Early and effective treatment is essential to prevent the
morbidity and mortality associated with prolonged convulsive SE. Lorazepam is the standard of
care for control of SE when administered by intra-venous (IV) route. The investigators intend
to compare efficacy and adverse effect profile of intra-nasal vs. intravenous routes of
administration of lorazepam. In resource poor settings, sometimes trained personnel or
appropriate equipment for intra-venous cannulation is not available. Alternate routes of
administration, if shown equivalent to conventional IV route, will be very useful in such
settings or for out of hospital management of seizures in children.
Phase:
Phase 3
Details
Lead Sponsor:
All India Institute of Medical Sciences, New Delhi