Overview
Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients
Status:
Recruiting
Recruiting
Trial end date:
2022-10-01
2022-10-01
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
The aim of the current study is to compare miscarriage rates (before 8 weeks) between a true natural cycle (awaiting spontaneous LH surge) and a hormone replacement therapy cycle prior to blastocyst transfer in preimplantation genetic testing (PGT) patients, with biopsy on day 5 of embryonic development. The advantage of performing the study in PGT patients is the exclusion of aneuploidy as a cause of miscarriage.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
CRG UZ BrusselTreatments:
Estradiol
Estradiol 17 beta-cypionate
Estradiol 3-benzoate
Follicle Stimulating Hormone
Hormones
Polyestradiol phosphate
Progesterone
Criteria
Inclusion Criteria:- BMI under 35 kg/m2
- Regular menstrual cycle pattern (i.e. 24-35 days cycle)
- First, second and third ICSI-PGT cycle
- First frozen embryo transfer cycle following a fresh ICSI-PGT attempt
- PGT with trophectoderm biopsy on day 5 of embryonic development
- Signed informed consent
Exclusion Criteria:
- Oligo-amenorrhea
- BMI above 35
- Contraindications for the use of hormonal replacement therapy