Overview

Natural Killer (NK) Cell Therapy for B-Cell Malignancies

Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
This is an open-label, Phase I study of QN-019a (allogeneic CAR-NK cells targeting CD19) as monotherapy in relapsed/refractory B-cell Acute Lymphoblastic Leukemia (B-ALL) and in combination with Rituximab in relapsed/refractory B-cell Lymphoma. This clinical study is to evaluate the safety, tolerability and preliminary efficacy of QN-019a in patients with relapsed/refractory B-cell lymphoma or B-ALL. Up to 22-36 patients will be enrolled.
Phase:
Phase 1
Details
Lead Sponsor:
Zhejiang University
Collaborator:
Hangzhou Qihan Biotech Co.,Ltd.
Treatments:
Cyclophosphamide
Fludarabine
Rituximab