Natural Progesterone and Preterm Birth in Twins

• Status: Completed
• Trial end date: 2007-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

To assess the effectiveness of natural progesterone supplementation in preventing preterm births in twins.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA
• Treatments: Progesterone

Criteria

Inclusion Criteria:

• Bichorionic biamniotic twin pregnant women

• = or > 18 years old

Exclusion Criteria:

• Single pregnancy or monochorionic twin pregnancy or triplets

• Chronic hepatic pathology, previous alterations in hepatic analysis during anti-contraceptive treatment; or gestational cholestasis in in previous pregnancies.Basal alterations in hepatic analysis profile.

• Profylactic cerclage until week 14.

• Basal alterations in renal analysis profile

• Local allergy to micronized natural progesterone

• Genital pathology not allowing for correct absorption of medication

• Fetal anomoly diagnosed after sonograph week 12 and/or 20.

• Smokers of more than 10 cigarettes/day

• Consumers of illegal substances