Near Normalisation of BG Improves the Potentiating Effect of GLP-1

• Status: Completed
• Trial end date: 2004-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to I.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near-normalisation og blood glucose improves the potentiation of glucose-stimulated insulin secretion by GLP-1

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hvidovre University Hospital
• Treatments: Glucagon; Glucagon-Like Peptide 1

Criteria

Inclusion Criteria:

• Age 18-70 years

• Type 2 diabetes diagnosed after 30 years of age

• BMI > 25

Exclusion Criteria:

• Severe complications to diabetes

• Abnormal liver og kidney function

• Haemoglobin below the lower limit

• Macroalbuminuria

• Systemic disease

• Pregnancy