Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With AECOPD

• Status: Completed
• Trial end date: 2017-09-30
• Target enrollment: 0
• Participant gender: All

Summary

This randomised study was designed to assess the efficacy of nebulised heparin and salbutamol in improving lung function in mechanically ventilated patients with AECOPD.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Albuterol; Calcium heparin; Heparin

Criteria

Inclusion Criteria:

• > or = 18 years of age,

• body weight 70-110Kg,

• height 160-180 cm

• with clinically evident AECOPD and in need for mechanical ventilation confirmed by arterial blood gases (ABGs).

Exclusion Criteria:

• Excluded Patients from the study were those who were not enrolled within the first 24 hours of mechanical ventilation and those who were likely to be extubated within 24 hours. - History of ischemic heart disease,

• History of pulmonary bleeding within the previous 3 months,

• History of bleeding diathesis,

• Known to be allergic to heparin or

• History of thrombocytopenia after previous treatment with heparin.

• Female patients were excluded if they were pregnant or breast feeding.