Nebulized Heparin for Prevention of Acute Lung Injury in Smoke Inhalation Injury

• Status: Recruiting
• Trial end date: 2023-09-30
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to examine the value of nebulized heparin for prevention of acute lung injury in adult patients suffering smoke inhalation injury.

Patients will be randomized to receive nebulized heparin or an equal volume of normal saline for 14 days and the incidence of acute lung injury will be compared in either group.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Heparin

Criteria

Inclusion Criteria:

1. Adult patients indicated for elective intubation:

• History of being trapped in a house or industrial fire.

• Production of carbonaceous sputum.

• Perioral facial burns affecting nose, lips, mouth, or throat .

• Altered level of consciousness at any time after the incident and including confusion.

• Symptoms of respiratory distress including a sense of suffocation, choking, breathlessness, and wheezing or discomfort affecting the eyes or throat, including irritation of the mucosal membranes.

• Signs of respiratory distress including stertorous or labored breathing, and tachypnea or auscultatory abnormalities, including crepitations or rhonchi.

• Hoarseness or loss of voice. 2. Evidence of bronchial burn by bronchoscopy to assess severity of inhalational trauma

• NO injury: absence of carbonaceous deposits, erythema, oedema, brochorrhea, or obstruction.

• Mild injury: minor patchy areas of erythema or carbonaceous deposits in proximal or distal bronchi.

• Moderate injury: moderate degree of erythema, carbonaceous deposits, bronchorrhea, or bronchial obstructions.

• Sever injury: sever inflammation with friability, copious carbonaceous deposits, bronchorrhea, or obstruction.

• Massive injury: evidence of mucosal sloughing, necrosis or endoluminal obliteration.

3. No evidence of acute lung injury at presentation (either by radiology or ABG)

• Radiological findings: Normal lung without increased interstitial markings, ground glass opacification, or consolidation.

• ABG findings : PaO2/ Fio2 > 300. 4. Time between inhalational injury and intubation not longer than 24 hours.

Exclusion Criteria:

1. Burn injury > 24 hours.

2. History of pulmonary diseases.

3. Pregnancy or breast feeding.

4. History of allergy to heparin or HIT.

5. History or laboratory evidence of coagulopathy.

6. Burns area > 50% of total body surface area. -