Nebulized Hypertonic Saline for Mechanically Ventilated Children

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Children who need to be on a ventilator often have thick secretions/mucus in their lungs. These secretions can obstruct the breathing tube and their windpipe, which can worsen lung function and prolong the need for the ventilator. Hypertonic saline is a medicine that is used to thin out secretions in patients with cystic fibrosis (and other conditions). We hypothesize that having children on a ventilator inhale this medication will shorten the amount of time that they need to be on the ventilator.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospitals Cleveland Medical Center

Criteria

Inclusion Criteria:

• invasive mechanical ventilation of < 12 hrs duration prior to enrollment

• expected duration of mechanical ventilation of > 48hrs from enrollment

• age < 18yo

Exclusion Criteria:

• inclusion in another clinical study

• cystic fibrosis

• status asthmaticus

• pulmonary hemorrhage/contusion

• home O2 use

• home non-invasive positive pressure (CPAP/BiPAP) ventilation use

• pre-existing tracheostomy

• prescription of mucolytic medication by primary clinical team

• allergy to inhaled saline/hypertonic saline or albuterol