Nebulized Lidocaine, Dexmedetomedine and Their Combination in Direct Laryngoscopy Surgery

• Status: Completed
• Trial end date: 2021-07-11
• Target enrollment: 0
• Participant gender: All

Summary

Direct laryngoscopy (DL) procedure is typically done under general anaesthesia as a day case. It is a short but irritating.Various drugs and drug combinations have been used to attenuate stress response to DL.Administrating nebulized form of drugs can be effective with less systemic side effects. The primary outcome of this study is to compare the effect of premedication with nebulized lidocaine, dexmedetomidine, combination of both to placebo on haemodynamic response during DL procedures.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Dexmedetomidine; Lidocaine

Criteria

Inclusion Criteria:

• ASA I-III patients admitted for DL surgery.

Exclusion Criteria:

• Uncontrolled hypertension (MAP > 100 mmHg) or ischaemic heart disease.

• End stage renal impairment.

• Chronic drug or alcohol abuse.

• Predicted difficult airway, laryngoscopy and intubation time > 30 sec, more than one attempt of intubation.

• Morbid obesity (BMI > 30).

• Known allergy to the drugs used.