Nefopam for Post Video-Assisted Thoracoscopic Lobectomy

• Status: Recruiting
• Trial end date: 2022-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Video-assisted thoracoscopic (VATs) lobectomy is mild to moderately pain procedure. For conventional thoracotomy, there are many invasive pain control such as epidural analgesia, paravertebral block. However, for VATs, the invasive pain control somehow are too invasive. Nefopam is non-opioid painkilling medication, Serotonin, norepinephrine, dopamine reuptake inhibitor. Many study were demonstrated positive outcome of nefopam usage in many operation such as abdominal surgery, laparocopic surgery, orthopedic surgery. Nevertheless, nefopam for VATs is not well studied yet.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mahidol University
• Treatments: Nefopam

Criteria

Inclusion Criteria:

• Schedule to video-assisted thoracoscopic surgery : VATs lobectomy

• Can operate a patient-controlled analgesia (PCA) device

• No contraindication for nefopam

Exclusion Criteria:

• Epilepsy, on monoamine oxidase (MAO) inhibitors, glaucoma

• Creatinine clearance < 60 ml/min

• Liver disease: child-pugh score B or C

• Allergy to nefopam

• Chronic opioid use