Neoadjuvant Chemotherapy Followed by Surgery Versus Concurrent Chemoradiation in Carcinoma of the Cervix
Status:
Unknown status
Trial end date:
2020-07-31
Target enrollment:
Participant gender:
Summary
Carcinoma cervix is a common malignancy in women in developing countries including India. The
standard treatment of locally advanced cervical cancer (Stages IB2 to IIIB)is concomitant
chemoradiation (CT RT) using platinum based chemotherapy. Some studies, including a
meta-analysis conducted by the Cochrane group, have indicated that few courses of neoadjuvant
chemotherapy (NACT) followed by surgery may be superior to radical radiation alone for these
patients. However NACT-Surgery approach has never been compared to the current standard of
concomitant CT RT. The present study is undertaken to compare, in a randomized trial, NACT(3
courses of paclitaxel-carboplatin) followed by surgery to concomitant CT RT in stages IB2 to
IIB squamous cell carcinoma of the uterine cervix.