Neoadjuvant Chemotherapy and Radical Surgery in Stage IIB Cervical Cancer

• Status: Unknown status
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

Neoadjuvant chemotherapy (NACT) and radical surgery (RS) may have a possible better outcome to concurrent chemoirradiation (CCRT) in stage IIB cervical cancer. We try to verify such a hypothesis in terms of survival and treatment related morbidity.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Sun Yat-sen University
• Treatments: Cisplatin; Paclitaxel

Criteria

Inclusion Criteria:

• Patients with newly histologically confirmed cervical carcinoma

• Original clinical stage must be IIB （FIGO 2009）

• Histopathology squamous carcinoma, adenocarcinoma or adeno-squamous carcinoma

• Age between 18-65

• Patients must give signed informed consent

Exclusion Criteria:

• The presence of uncontrolled life-threatening illness

• Receiving other ways of anti-cancer therapy

• Investigator consider the patients can't finish the whole study

• With normal liver function test (ALT、AST>2.5×ULN)

• With normal renal function test (Creatinine>1.5×ULN)

• WBC<4,000/mm3 or PLT<100,000/mm3