Neural Correlates of Lidocaine Analgesia

• Status: Recruiting
• Trial end date: 2023-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to characterize the effects of intravenous lidocaine on pain processing and cognitive function. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will consist of 1 visit and involves no long-term follow up.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Keith M. Vogt, MD, PhD
• Collaborator: National Institute of General Medical Sciences (NIGMS)
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• Adults aged 18 to 70

• Be of normal body-weight

• Be generally healthy

• Have none of the specific exclusion criteria

• Have a valid email address and phone number throughout the study

Exclusion Criteria:

• Pregnancy

• Body mass index > 40

• Having chronic pain requiring the regular use of pain medicine

• Having neurologic or psychiatric disease, including anxiety, and depression

• Having history of cardiac rhythm disturbance (such as heart block, or atrial fibrillation)

• Being severely claustrophobic

• Having metal implants or non-removable metal piercings

• Having metal-containing tattoos, particularly on the face

• Having a history of adverse reaction to lidocaine

• Are regularly taking: antiepileptics, antidepressants, anti-psychotics, anti-anxiety medication, stimulants, sleep-aids, or pain medication