Neural Mechanism of Aldosterone-induced Insulin Resistance

• Status: Recruiting
• Trial end date: 2025-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients with high aldosterone hormone have higher blood glucose than normal people. This study is being done to understand how aldosterone hormone affects the nerve activity that controls blood flow in the muscles and blood glucose. The information may be helpful in selecting blood pressure medications which can improve not only blood pressure but also improve blood sugar.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Texas Southwestern Medical Center; Wanpen Vongpatanasin
• Treatments: Insulin; Insulin, Globin Zinc; Nitric Oxide; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

1. Normotensive controls

2. Stage I (140-159/90-99 mmHg) untreated subjects with essential hypertension

3. Patients with PA and stage I (140-159/90-99 mmHg) hypertension

Exclusion Criteria:

1. Congestive heart failure or coronary artery disease

2. Blood pressure averaging > 159/99 mmHg

3. Serum creatinine > 1.5 mg/dL

4. Diabetes mellitus or other systemic illness

5. Left ventricular hypertrophy by echocardiography or ECG

6. Pregnancy

7. Hypersensitivity to spironolactone, chlorthalidone, amlodipine, human recombinant insulin or Definity

8. Any history of substance abuse (other than tobacco)

9. History of gouty arthritis

10. Patients with right-to-left, bi-directional, or transient right-to-left cardiac shunts

11. Hypersensitivity to perflutren, blood, blood products or albumin