Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults

• Status: Recruiting
• Trial end date: 2023-06-30
• Target enrollment: 0
• Participant gender: All

Summary

Emerging adults are a particularly vulnerable group for experiencing the immediate and potentially lifelong negative impacts of habitual cannabis use, and trends suggest that cannabis use disorder (CUD) will soon escalate in this population. The proposed research will combine clinical pharmacology, non-invasive brain stimulation, and neuroimaging techniques to establish the brain mechanisms of cannabinoid-impaired decision-making processes in emerging adults with CUD. Results from this project will inform CUD prevention/treatment efforts in this high-risk group and address a growing public health concern.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Michael J. Wesley, PhD; University of Kentucky
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Dronabinol

Criteria

Inclusion Criteria:

• Habitual cannabis use problems

• Body Mass Index ≤30

Exclusion Criteria:

• Past or current serious physical or mental health

• Sesame seed oil allergy

• Irregular health issues identified by the Study Physician

• Standard magnetic resonance imaging and transcranial magnetic stimulation exclusion criteria (e.g., metal implants, history of epilepsy, etc.)

• Lack of affective form of birth control (females)

• Pregnancy (females)