Neural Pressure Support for Low Pulmonary Compliance

• Status: Not yet recruiting
• Trial end date: 2023-10-31
• Target enrollment: 0
• Participant gender: All

Summary

With this interventional prospective study, we aim at comparing the effectiveness of NPS in reducing respiratory work and patient-ventilator asynchronies as compared with standard PSV, in a cohort of patients with ARF and low respiratory system compliance.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Policlinico Hospital

Criteria

Inclusion Criteria:

• Age > 18 y.o.

• Admission to ICU for ARF

• Low compliance of the respiratory system (Crs ≤ 30 ml/cmH2O)

• Written informed consent obtained

Exclusion Criteria:

• Contraindication to nasogastric tube insertion (gastroesophageal surgery in the previous 3 months, gastroesophageal bleeding in the previous 30 days, history of esophageal varices, facial trauma)

• Increased risk of bleeding with nasogastric tube insertion, due to severe coagulation disorders and severe thrombocytopenia ( i.e., INR > 2 and platelets count < 70.000/mm3)

• Severe hemodynamic instability (noradenaline > 0.3 μg/kg/min and/or use of vasopressin)

• Failure to obtain a stable EAdi signal

• Central nervous system or neuromuscular disorders

• Moribund status