Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction

• Status: Completed
• Trial end date: 2017-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims at testing for the impact of glutamatergic changes on drug craving in cocaine addiction, and to evaluate the effects of n-acetylcysteine (n-AC) on both glutamate homeostasis and craving using a randomized, double-blind, placebo controlled cross-over design.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Psychiatric University Hospital, Zurich
• Collaborators: Max-Planck-Institut Tübingen; Swiss Federal Institute of Technology; Zurich Center for Integrative Human Physiology
• Treatments: Cocaine

Criteria

Inclusion Criteria:

• Cocaine use disorder vs. no substance use

• Magnetic resonance imaging compatibility

Exclusion Criteria:

• Regular use of other psychoactive drugs

• Comorbidity of other psychiatric disorders

• Neurological or somatic disease