Neurobiological Basis of Response to Guanfacine Extended Release in Children and Adolescents With ADHD
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
This study proposes to evaluate the effects of guanfacine extended release on brain
activation during fMRI in children and adolescents with ADHD between the ages 8-15 and ADHD
subjects randomized to placebo treatment.
This study also proposes to collect DNA on study participants, to examine the genetic
underpinning of the observed fMRI activation profiles at baseline and in response to
treatment. The purpose is to examine polymorphisms of the adrenergic 2A gene (and other
related targets) for genetic biomarkers in association with the fMRI findings of this study.