Neurobiological Effects of Oxytocin in Schizophrenia
Status:
Recruiting
Trial end date:
2022-04-01
Target enrollment:
Participant gender:
Summary
22 male patients with schizophrenia and 22 male healthy volunteers will be included in the
study. Subjects who meet the inclusion and exclusion criteria for the study will be
recruited. After completion of clinical assessments and neuropsychological assessments, all
subjects will undergo two multi-modal imaging sessions. In one scan they will receive
intranasal oxytocin and in another scan will receive intranasal saline as control. The order
of administration of the medication will be counterbalanced and subjects will be blind to the
medication administered. Using the simultaneous PET-MRI scanner, PET and fMRI data will be
collected simultaneously. Blood will be collected for analysis of oxytocin receptor gene
polymorphism and its potential effect on brain activity.
Phase:
N/A
Details
Lead Sponsor:
National Institute of Mental Health and Neuro Sciences, India