Neurobiological Underpinnings of Placebo Response in Depression
Status:
Recruiting
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
In summary, the proposed research is novel with respect to design, technology, and its
multi-level integration probing psychological and neurobiological constructs assumed to be
crucially implicated in placebo response and has significant clinical and research
implications for the future. Specifically, the future implications include: 1) identification
of biomarkers and biosignatures of placebo responders, 2) new possibilities to understanding
and manipulating the system, 3) possibly decreasing or eliminating a major confounder in
clinical trials and drug development, and 4) refining treatments with novel drugs that
decrease (in clinical trial) or increase (in clinical practice) the placebo response.