Neurobiological and Neurocognitive Disturbances in First-episode Schizophrenia
Status:
Completed
Trial end date:
2008-09-01
Target enrollment:
Participant gender:
Summary
We want to relate disturbances in first-episode schizophrenic patients in serotonin 5-HT2A
receptors, brain structure, brain function, and information processing to each other and to
psychopathology. Additionally, we want to examine the influence of 5-HT2A receptor blockade
on these disturbances. We expect disturbances in the serotonergic system at baseline to
correlate with specific structural and functional changes and with disruption in information
processing as measured with psychophysiological and neurocognitive methods - and we expect
5-HT2A receptor blockade to reverse some of the functional and cognitive impairments. We do
not expect any effect of treatment on brain structure
Phase:
N/A
Details
Lead Sponsor:
Birte Glenthoj
Collaborators:
AstraZeneca Copenhagen Hospital Corporation Copenhagen University Hospital, Hvidovre Glostrup University Hospital, Copenhagen Rigshospitalet, Denmark The Danish Medical Research Council University of Copenhagen