Neurocognitive Mechanisms of Perimenstrual Estrogen Effects on Suicidality
Status:
Recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
This within-person, crossover, 2-condition, placebo-controlled study compares the impact of
two perimenstrual conditions on severity of suicidal symptoms in females with past-month
suicidality but minimal risk of imminent suicide attempt. The two conditions are (1)
perimenstrual administration of estradiol and (2) natural perimenstrual withdrawal from
estradiol during placebo.