Neurocognitive Performance and Emotional State in HCV Patients With IFN-free Antiviral Therapy
Status:
Unknown status
Trial end date:
2017-04-01
Target enrollment:
Participant gender:
Summary
The present study evaluates neurocognitive performance as well as measures of mood, quality
of life, and fatigue in patients with chronic hepatitis C infection. In a prospective
longitudinal study design, included patients are monitored before, during, and in the
long-term follow-up of interferon-free antiviral treatment (Sofosbuvir +/-Daclatasvir +/-
Ribavirin or Sofosbuvir/Ledipasvir +/- Ribavirin). Main study goals are to compare post
therapy results of sustained virologic responders to corresponding pretreatment values as
well as to historic interferon-treatment patients without virological response. It is
expected that HCV-associated neuropsychiatric symptoms and neurocognitive impairment is - at
least in part - reversible by the successful application of modern IFN-free antiviral
medication.