Neuroimaging Mechanisms by Which Memory and Glucocorticoids Promote Risky Drinking

• Status: Recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether hydrocortisone biases formation of alcohol-related memories to potentiate drinking.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yale University
• Treatments: Hydrocortisone

Criteria

Inclusion Criteria:

• Able to read and write English

• BMI 18-35

• Beer drinking

Exclusion Criteria:

• Meet current criteria for any substance use disorder, excluding caffeine

• Current significant medical conditions or psychiatric symptoms requiring medication

• Current use of medications/drugs that interfere with the HPA axis response

• Peri and post-menopausal women, pregnant or lactating women, and those with hysterectomies

• Metal in body (for MRI safety)

• Systemic fungal infections (contraindication for hydrocortisone)

• Known hypersensitivity to components of hydrocortisone tablets (hydrocortisone, calcium stearate, corn starch, lactose, mineral oil, sorbic acid, sucrose)