Neuroinflammation and Age-associated Brain Pathology: Two Potential Mechanisms of Cognitive Impairment in Breast Cancer
Status:
Recruiting
Trial end date:
2024-07-01
Target enrollment:
Participant gender:
Summary
This study will use a PET/MRI scanner and an investigational radioactive drug called
[F-18]DPA-714 that measures inflammation in the brain, also called neuroinflammation, before
chemotherapy and after 3 to 6 cycles of chemotherapy given as part of your clinical care. In
addition, this study will use a PET/MRI scanner with an investigational radioactive drug
called [C-11]PiB that measures the amount of abnormal protein (called beta-amyloid) in the
brain that is a marker of Alzheimer's disease pathology.
One of the most common complaints among breast cancer survivors is cognitive or memory
problems especially in older adults. Researchers need to better understand the mechanisms and
risk factors for cognitive problems in order to address this problem. This study seeks to
examine two mechanisms, neuroinflammation and amyloid deposition, that have been suggested in
other age-related cognitive disorders. This study may help physicians and researchers develop
new treatments to protect the brain in cancer patients. UAB plans to enroll 20 participants
in this study.