Neuroleptic and Huntington Disease Comparison of : Olanzapine, la Tetrabenazine and Tiapride

• Status: Completed
• Trial end date: 2017-04-28
• Target enrollment: 0
• Participant gender: All

Summary

Huntington's disease (HD) is autosomal dominant neurodegenerative disease, starting in average (with high variability) in the fourth decade. The disease progression is classically characterized by a cognitive deterioration (cortical-frontal dementia), motor disorders (associating chorea, dystonia and bradykinesia), psychiatric disturbances (combining depression and irritability) and metabolic disorder (cachexia). The disease is fatal within 15 to 20 years in most patients. HD has no cure. Neuroleptics are the main drug used and the only to demonstrate its efficacy on chorea in clinical trials. But neuroleptics have also beneficial and adverse effects on other disease characteristics (motor, psychiatric, cognitive or metabolic). Their profile between beneficial and adverse effects could be different according the neuroleptics and their classification. The aim of this study is to compare beneficial and adverse effects of 3 different neuroleptics in HD.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Antipsychotic Agents; Olanzapine; Tetrabenazine; Tiapride Hydrochloride

Criteria

Inclusion Criteria:

1. Symptomatic disease with motor, behavioural and/or psychiatric disorder required medical treatment.

2. HD diagnosed with abnormal number of CAG repeats: 38 ≤ nucleotide expansion (CAG) (amendment n°5 suppressed the limit ≤ 48)

3. Neuroleptic Prescription required.

4. Age ≥ 18 (amendment n°5 suppressed the limit ≤ 65 years old)

5. Patient gave its written consent

6. Realization of medical examination and a Electroencephalogram

Exclusion Criteria:

1. Severe cognitive impairment or neuropsychiatric troubles.

2. Existing diabetes.

3. Neuroleptic prescription forbidden according to the neurologist decision.

4. Current participation to another clinical trial.

5. No drug compliance to previous treatment.

6. No national health insurance affiliation