Neuromuscular Blockade in Patients With Severe Renal Impairment
Status:
Recruiting
Trial end date:
2022-07-01
Target enrollment:
Participant gender:
Summary
This study is intended to be a single-site, prospective, randomized, double-blinded study
that intends to enroll a total of 60 patients with severe renal impairment undergoing surgery
with general endotracheal anesthesia at Parkland Hospital. Patients will be randomized to
receive either neostigmine (for reversal of cisatracurium) or sugammadex (for reversal of
rocuronium). A standardized anesthetic protocol that is usual and customary for the type of
operation the patient is having will be provided to the anesthesia teams of enrolled
subjects. The remainder of the anesthetic care of the subject will not deviate from the
standard of care. All patients will be monitored with continuous pulse oximetry
postoperatively for 24 hours.