Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition
Status:
Completed
Trial end date:
2016-10-13
Target enrollment:
Participant gender:
Summary
Understanding the neural and biological mechanisms by which reproductive hormones influence
mood is critically important for public health given that postpartum depression (PPD) is the
leading cause of morbidity and mortality associated with childbirth and has negative effects
on infants. Using a hormone-withdrawal challenge to precipitate mood symptoms will improve
our ability to identify the biological mechanisms underlying both the triggering of and
susceptibility to depressive disorders in women; and will permit the prediction of those at
risk for PPD and other reproductive-related mood disorders.
Phase:
N/A
Details
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborators:
Foundation of Hope, North Carolina National Alliance for Research on Schizophrenia and Depression National Institute of Mental Health (NIMH) National Institutes of Health (NIH) North Carolina Translational and Clinical Sciences Institute