Neurosteroids in PTSD - Biomarkers to Therapeutics
Status:
Terminated
Trial end date:
2020-11-16
Target enrollment:
Participant gender:
Summary
The purpose of this research is to determine if a study medication called
Dehydroepiandrosterone (DHEA) helps to reduce PTSD symptoms in OEF/OIF/OND Veterans. In
addition to finding out if DHEA is effective for treating PTSD symptoms, this research seeks
to determine if DHEA is effective in treating other symptoms, such as depression and anxiety.
Depression and anxiety are symptoms that are frequently present in Veterans who are
experiencing PTSD. Another purpose of this research is to takes pictures of the brain using
magnetic resonance imaging (MRI) and blood levels of various small molecules including
neurosteroids and also proteins, which may be affected by the study drug and/or related to
symptoms in Veterans with PTSD. This study seeks to determine if DHEA is changed to other
compounds after it is taken by mouth and the safety and effectiveness of DHEA in Veterans
with PTSD. This is an "add-on" study and Veterans enrolled in the study will continue to take
all of their current medications without any changes (also called "usual care"), and DHEA or
a sugar pill (also called a "placebo") will then be added to their current medication
regimen.