New Approach of Assessing Drug Response for Treatment of Nasopharyngeal Cancer

• Status: Completed
• Trial end date: 2017-03-03
• Target enrollment: 0
• Participant gender: All

Summary

The combination of pEBV DNA (half-life) and PET-CT following 1 course of chemotherapy allow earlier and more detection of drug response in advanced NPC than RECIST method, in patients with previously untreated advanced NPC who will receive platinum-based chemotherapy. This study will also determine if this new method can predict survival in these patients. This study may have far-reaching impact on drug development in NPC as it may offer a more optimal way of evaluating drug efficacy in clinical trials and also in clinical management.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese University of Hong Kong

Criteria

Inclusion Criteria:

• undergo chemotherapy for any one of the following settings:

1. Setting 1: Neoadjuvant chemotherapy prior to cheom-RT

2. Setting 2: Palliative chemotherapy in Chemonaive patients

3. Setting 3: Palliative chemotherapy in previously treated patients (i.e. 2nd line or 3rd line chemo)

• Age >= 18 years

• (ECOG) performance status of 0-2

• have detectable levels of pEBV DNA at baseline

• have measurable tumor sites by RECIST criteria

• have adequate bone marrow, renal and hepatic functions