New Cross Linked Hyaluronan Gel After Deep Infiltrating Endometriosis Surgery
Status:
Completed
Trial end date:
2019-06-01
Target enrollment:
Participant gender:
Summary
Hyaluronan, a glycosaminoglycan found in connective tissues and extracellular matrix, has
been postulated to reduce postoperative adhesions, because of its unconditioned biological
functions at tissue repair but unfortunately it has a fluid nature that causes rapid
degradation, and it cannot effect long enough to work as an adhesion barrier.(10,11) For this
reason a New cross-linked hyaluronan (NCH) gel, that has higher viscosity compared to natural
hyaluronan has been developed by BioRegen Biomedical (Changzhou, Jiangsu, China). It has the
ability for gradually absorption within 1 to 2 weeks in vivo, which are the acquired repair
period and the critical time for adhesion formation. Although it seems evident that
endometriosis has a serious impact on the daily Quality of Life of women; comparable data for
the effect of adhesion barriers to patients who have had laparoscopic (Deep infiltrating
endometriosis) DIE surgery is missing.
Therefore a pilot randomised controlled study was conducted to evaluate the effect of NCH gel
on short term quality of life in patients who had undergone laparoscopic surgery due to DIE.
Phase:
N/A
Details
Lead Sponsor:
Bakirkoy Dr. Sadi Konuk Research and Training Hospital