New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin

• Status: Completed
• Trial end date: 2019-12-20
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study is to determine whether the association of Melatonin and Hyaluronic Acid to the antimicrobial TM paste (3% Tetracyclin and 3% Metronidazole) for periodontal maintenance therapy can improve the attachment level (AL) and alveolar bone support for moderate chronic periodontitis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Concordia Dent Srl
• Collaborators: Carol Davila University of Medicine and Pharmacy; Romanian National Authority for Scientific Research and Innovation (UEFISCIDI); TURKEY MEDISEN Ltd; University Politechnica of Bucharest
• Treatments: Hyaluronic Acid; Melatonin; Metronidazole; Tetracycline

Criteria

Inclusion Criteria:

• moderate chronic periodontitis, that is, > 2 interproximal sites with AL > 4 mm (not on the same tooth), or > 2 interproximal sites with pocket depth (PD) > 5 mm (not on the same tooth) (1),

• at least 20 teeth present in the mouth,

• no periodontal therapy during the last 6 months,

• no antibiotic during the last 6 months,

• good general health (no systemic condition affecting the course of periodontal disease, including malignancy), pregnancy,

• no allergy to the product components,

• good mental health.

Exclusion Criteria:

• Patients not willing to sign consent form.

• Patients not agreeing with the treatment protocol.