Overview

New Perspective on Exploring the Post-apneic BP Surge in Patients With OSA

Status:
Recruiting

Trial end date:
2024-06-01

Target enrollment:
0

Participant gender:
All

Summary

The nocturnal short-term BPV induced by sleep-breathing events is affected by many factors. The purpose of the study is as follows: (1) to explore the relationship between nocturnal short-term BPV and vascular endothelial function and sympathetic activity in patients with OSA respectively, (2) to explore which play the key role in BP fluctuation, (3) how to prevent the frequent BP fluctuation and arrive at a safe point.

Phase:

Early Phase 1

Accepts Healthy Volunteers?

Accepts Healthy Volunteers

Details

Lead Sponsor:

Xu J

Treatments:

Nitroglycerin
Phentolamine

Criteria

Inclusion Criteria:

- medium to severe OSA (apnea-hypopnea index, AHI≥15 events/h) and patients without OSA
(AHI<5 events/h)

- age from 18 to 65 years old.

Exclusion Criteria:

- combined with other sleep disorders

- patients with comorbidities, such as hypertension, diabetes, cardiovascular diseases,
and cerebrovascular diseases etc

- conditions that potentially affect the accuracy of BPV and endothelial function

- ever-received the treatment of constructive positive airway pressure (CPAP)

- who refuse to participate in the study.