New Treatment for COVID-19 Using Ethanol Vapor Inhalation .

• Status: Not yet recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Since ARDS is a major complication of COVID - 19 with subsequent formation of non-cardiogenic pulmonary edema , worsening the oxygenation of the patients and foamy and even bloody sputum formation, so the idea is to use alcohol inhalation as it reduce surface tension on the alveoli and markedly decrease sputum formation with improvement on oxygenation beside its cytolethal effect on virus lipid bilayer.

A lot of researches and publications proved the role of alcohol inhalation in treatment of pulmonary edema. Alcohol inhalation may has inflammatory effect and dangerous effect on patients but this can be controlled by the actual concentration used and the way we use it according to general condition of the patient and with the help of anti - inflammatory action of Asprin .

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Ethanol

Criteria

Inclusion Criteria:

• Age from 20 - 60

• Confirmed COVID-19 positive with PCR test .

• Admitted to Mansoura university quarantine hospital ..

• Fever ≥ 38

• Respiratory rate ≥ 20

• Myalgia , Arthralgia and Sore throat .

• Radiological findings consisting with COVID-19 .

• Welling to participate and able to give fully informed consent. Specific inclusion criteria according to the concentration and method :-

• Inhalation of Alcohol vapor driven by Oxygen Respiratory distress ( Dyspnea - Orthopnea ) Spo2 : 65 - 85 ABG : Respiratory Alkalosis due to dyspnea and tachypnea PaO2 / FIO2 ratio > 300 mmHg under the condition in the hospital room (Moderate illness).

• Inhalation of Alcohol vapor driven by oxygen in case of ARDS. Respiratory failure . CT : lobar collapse and nodules Non cardiogenic pulmonary edema excluded by ECHO or signs of overload . PaO2 / FIO2 ratio 101 - 300 mmHg on CPAP or Vent . ( Mild to moderate ARDS)

• Ethyl Alcohol infusion into the airway PaO2 / FIO2 ratio ≤ 100 mmHg ( Sever ARDS )

Exclusion Criteria:

• Absence of any item from inclusion criteria

• Pregnancy .

• Signs of dehydration , Sepsis or shortness of breathing.

• Asthmatic patients .

• COPD .

• Smokers ≥ 10 years .

• Hypersensitivity to Alcohol