Nicardipine vs Esmolol Craniotomy Emergence

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Emergence hypertension is a common occurrence in patients emerging from general anesthesia. This elevation of arterial pressure is particularly concerning in patients undergoing craniotomy due to increased risk of morbidity and mortality in patients with altered intracranial elastance. Thus, identifying better methods to attenuate the hemodynamic changes associated with emergence from anesthesia can improve patient safety, especially in the neurosurgical patient.

Study Hypothesis: Nicardipine is more effective than esmolol as a sole agent in maintaining blood pressure within goal range in the setting of emergence hypertension after craniotomy.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northwestern University
• Treatments: Esmolol; Nicardipine

Criteria

Inclusion Criteria:

• Adult

• non-pregnant patients

• (age ≥ 18 years)

• undergoing general anesthesia for elective supratentorial, infratentorial, or transsphenoidal craniotomy

Exclusion Criteria:

• Patients under 18 years of age

• non-English speaking, pregnancy

• emergent craniotomy (including trauma)

• awake craniotomy

• active 3 vessel coronary artery disease or left main coronary artery disease

• advanced heart block

• severe aortic stenosis

• chronic renal failure

• known or suspected allergy or intolerance to a study drug or its components