Overview

Nicardipine vs Esmolol Craniotomy Emergence

Status:
Completed
Trial end date:
2014-05-01
Target enrollment:
Participant gender:
Summary
Emergence hypertension is a common occurrence in patients emerging from general anesthesia. This elevation of arterial pressure is particularly concerning in patients undergoing craniotomy due to increased risk of morbidity and mortality in patients with altered intracranial elastance. Thus, identifying better methods to attenuate the hemodynamic changes associated with emergence from anesthesia can improve patient safety, especially in the neurosurgical patient. Study Hypothesis: Nicardipine is more effective than esmolol as a sole agent in maintaining blood pressure within goal range in the setting of emergence hypertension after craniotomy.
Phase:
Phase 1
Details
Lead Sponsor:
Northwestern University
Treatments:
Esmolol
Nicardipine