The purpose of this 3-year trial is to test the efficacy of transdermal nicotine patch versus
placebo patch on marijuana withdrawal symptoms in cannabis-dependent individuals, using a
randomized, double-blind, and placebo-controlled design. This proposal is in response to
RFA-DA-10-016(R01) Medications Development for Cannabis-Related Disorders. Consistent with
the goals of this RFA, the overall goal of the proposed project is to assess the impact of
transdermal nicotine patch (TNP) on marijuana (MJ) withdrawal (negative affect and craving
motivated by negative affect) symptoms in MJ-dependent individuals.