Nicotine Patch for Nicotine Dependence in Individuals With Schizophrenia or Schizoaffective Disorder - 1

• Status: Terminated
• Trial end date: 2005-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test the use of High-Dose versus Regular-Dose Nicotine Patch for Nicotine Dependence in Individuals with Schizophrenia or Schizoaffective Disorder

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Treatments: Nicotine

Criteria

Inclusion Criteria:

Subjects: 100 stable outpatients with schizophrenia and schizoaffective disorder and nicotine dependence. All subjects will meet the following inclusion criteria:

• Patients who are able to provide informed consent

• Patients will meet DSM-IV diagnostic criteria for Nicotine Dependence and Schizophrenia or Schizoaffective disorder

• Patients will be stable on their current antipsychotic regimen and will be interested in treatment for both their psychiatric and nicotine dependence

Exclusion Criteria:

• Potential subjects meeting the following criteria will be excluded:

• Patients with history of clinically significant angina or unstable angina pectoris

• Patients with severe CAD or recent myocardial infarction (within last 6 months)

• Patients with evidence or history of other severe medical illness (hematologic, renal or neoplastic)

• Patients who represent a serious suicide risk, including recent suicidal behavior or attempt within the last thirty days

• Patients with history of severe skin allergies or chronic dermatoses

• Concomitant use of clonidine or bupropion

• Pregnant females