Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers
Status:
Completed
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to better characterize differences in mood, attention, brain
activation patterns underlying the beneficial effects of pharmacological treatments
previously demonstrated to be help individuals successfully quit tobacco smoking. Smokers
will be randomly assigned to one of three treatments: 1) bupropion sustained release (SR), 2)
nicotine patch, or 3) placebo patches plus pills across a 45-day period with a 3-week
intensive post-treatment follow-up. In addition, 20 percent of the subjects will be
randomized to a delayed-quit control group.