Nicotine as an Adjuvant Analgesic for Third Molar Surgery

• Status: Completed
• Trial end date: 2009-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Third molar surgery is complicated by pain and swelling for several days after surgery. Non-steroidal antiinflammatory drugs have been useful in combination with opioids for treatment. Nicotine has antiinflammatory and pain relieving properties. We will use nicotine or placebo as a nasal spray before surgery to determine whether nicotine affects pain or inflammation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Columbia University
• Treatments: Nicotine

Criteria

Inclusion Criteria:

• over 18

• 4 molars to be removed

Exclusion Criteria:

• pregnant

• lactating

• chronic pain

• narcotic use

• asthma

• ex-smokers