Nicotinic Hepatic Metabolism on Neuroreceptor Substrates of Nicotine Addiction
Status:
Recruiting
Trial end date:
2023-09-01
Target enrollment:
Participant gender:
Summary
Physically healthy adult smokers may be eligible for this study. Volunteers may participate
in this study if they are 18 - 65 years old.
Subjects will participate in two separate 7-hour PET/CT Scan Sessions (each with 2 hours of
actual PET/CT scanning): one following an overnight abstinence and one following two
overnights of abstinence. To achieve and confirm two overnights of abstinence, participants
will present to the inpatient CHPS the day prior to the scheduled scan and stay overnight.
The 2-[18F]-FA PET/CT brain scans will consist of an injection followed by an 7-hour infusion
of 2-[18F]-FA. The scan session will begin at approximately 4 hours after the bolus
injection. The PET/CT scan will occur in two segments. Starting at approximately 4 hours post
bolus and infusion start, we will scan for approximately 90 minutes with a bolus injection of
IV nicotine that will occur approximately 15 minutes into the scanning procedure. There will
be a break in scanning of approximately 60 minutes, during which subjects will be allowed to
get off the scanner and use the restroom, if necessary. The second scan segment will start at
approximately 6.5 hours post bolus injection, t. This segment will last approximately 30
minutes. The pre and post nicotine images will be analyzed to evaluate for differences in
receptor uptake after the nicotine "challenge".
Subjects will have a structural Brain MRI performed within 1 year prior to study enrollment
or subjects who have not had a Brain MRI that is deemed acceptable for use for this study
will undergo a research Brain MRI after consent.