Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium

• Status: Unknown status
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Thiazide diuretics will be more effective in lowering urine calcium excretion if taken at night as compared to the daytime. It will therefore be more effective in reducing kidney stone recurrence in nephrolithiasis patients with elevated urine calcium who are known to have increased risk of kidney stones at night time.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: VA New York Harbor Healthcare System
• Treatments: Calcium, Dietary; Chlorthalidone; Diuretics; Hydrochlorothiazide; Sodium Chloride Symporter Inhibitors

Criteria

Inclusion Criteria:

• Patients with recurrent calcium kidney stones (at least 2 episodes) and either a higher urine calcium excretion (urine Ca >200 mg/d or > 4 mg/kg body weight) or,

• In patients who currently take a thiazide diuretic, a history of elevated urine calcium prior to medication use;

• Also capable of signing consent and doing 24-hour urine collections repeatedly.

Exclusion Criteria:

• Patients with primary hyperparathyroidism, renal tubular acidosis, chronic kidney disease (serum creatinine > 1.5 mg/dl), inflammatory bowel disease, gout,

• Patients taking thiazides with a history of hypertension,

• Patients with baseline systolic blood pressure less than 110mmHg