Nijmegen Antihypertensive Management Improvement Study

• Status: Completed
• Trial end date: 2011-03-01
• Target enrollment: 0
• Participant gender: All

Summary

High blood pressure is an important risk factor for diseases of heart and blood vessels like myocardial infarction and stroke. Many patients are not treated to target blood pressures, even though good blood pressure lowering drugs are available. Not all blood pressure drugs are equally effective in individual patients.

We hypothesize that individual patient characteristics can predict the best response on different blood pressure lowering drugs. In this study we will investigate whether a set of patient characteristics (anthropometric and laboratory) obtained before treatment may predict the blood pressure lowering response to representatives of two groups of drugs: those that inhibit renin-angiotensin system activity and those that decrease blood volume.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radboud University
• Treatments: Antihypertensive Agents; Hydrochlorothiazide; Valsartan

Criteria

Inclusion Criteria:

• Age 18-65 years with newly diagnosed hypertension in general practice

• hypertension is defined as either > 140 mm Hg systolic or > 90 mm Hg diastolic on three separate days.

Exclusion Criteria:

• History of cardiovascular disease (transient ischemic attack (TIA), stroke, myocardial infarction (MI), peripheral arterial disease (PAD), atrial fibrillation (AF), angina pectoris (AP), Diabetes Mellitus)

• Unable to understand and/or speak Dutch

• Severe hypertension (> 200/120 mmHg)

• Irregular pulse

• Use of antihypertensive medication

• Contraindication to one of the trial drugs

• Serious suspicion on secondary hypertension