Nitrate Supplementation and Cerebrovascular and Cognitive Function in Metabolic Syndrome

• Status: Not yet recruiting
• Trial end date: 2024-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if beetroot juice consumption can improve cognitive performance and brain vascular function in individuals with metabolic syndrome

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Penn State University

Criteria

Inclusion Criteria:

MetS classification according to NCEP III definition - MetS group only … at least 3 of the 5 components Individuals with a waist circumference >102 cm (40 in) for men > 88 cm for women Triglycerides ≥150 mg/dL HDL cholesterol ≤ 50 mg/dL for women and ≤ 40 mg/dL for men Blood pressure ≥130/85 mmHg Fasting blood glucose ≥100 mg/dL Age 55-75 Men and women All races and ethnicities

Exclusion Criteria:

1. Individuals with any overt cardiovascular, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s).

2. Premenopausal women - indicated by mention of last menstrual cycle

3. Individuals with active cancer

4. Individuals with moderate/severe depressive disorder as indicated by BDI-II scores (BDI-II score >14)

5. Individuals with cognitive impairment as indicated by the MMSE (score on the MMSE < 24)

6. Individuals with visual impairment

7. Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)

8. Individuals taking hormone replacement

9. Taking following an of the following medications:

1. nitrates (e.g. nitroglycerin) for angina

2. phosphodiesterase inhibitors (e.g., Viagra)

3. anti-Inflammatory drugs