Nitric Oxide Administration During Pediatric Cardiopulmonary Bypass Surgery to Prevent Platelet Activation
Status:
Completed
Trial end date:
2019-05-05
Target enrollment:
Participant gender:
Summary
Open heart surgery requires the use of a cardiopulmonary bypass (CPB) circuit. As blood flows
across the artificial surfaces of the CPB circuit, platelets are activated and consumed. This
activation results in a profound inflammatory reaction and need for transfusion. This
reaction is intensified in younger, smaller patients undergoing longer, more complex open
heart surgery. Nitric oxide is naturally released by vascular endothelial surfaces and acts
as a signaling molecule which prevents platelet activation. The investigators hypothesize
that the addition of the nitric oxide to the sweep gas of the oxygenator during
cardiopulmonary bypass surgery will replace this natural endothelial function and thus
prevent platelet activation and consumption. The investigators plan to test this hypothesis
with a pilot double blinded, randomized trial of 40 patients less than a year of age
undergoing cardiac surgery requiring CPB.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Medical College of Wisconsin
Collaborators:
Blood Center of Wisconsin Clinical & Translational Science Institute of Southeast Wisconsin Mallinckrodt Versiti