Nitric Oxide Effect on Brain and Kidney in Pediatric Patients Undergoing Cardiopulmonary Bypass
Status:
Not yet recruiting
Trial end date:
2022-11-01
Target enrollment:
Participant gender:
Summary
The goals of this study are:
1. To evaluate the neuroprotective effect of nitric oxide by measuring glial fibrillary
acid protein (GFAP) before and after surgery. GFAP will be analyzed via an enzyme-linked
immunosorbent assay (ELISA) kit. Patients will also be monitored post-operatively for
delirium in the intensive care unit (ICU).
2. To evaluate the renal protective effect of nitric oxide by measuring neutrophil
gelatinase-associated lipocalin (NGAL) before and after surgery. NGAL will also be
analyzed via an ELISA kit. Patient creatinine will be monitored post-operatively.
3. To evaluate effect of nitric oxide on other ICU outcomes (invasive mechanical
ventilation, days to extubation, ICU and hospital length of stay, and blood product
administration).