Nitric Oxide (NO) Donors and Inhibitors Study: Study to Evaluate L-Arginine and Aminoguanidine in Asthmatic Subjects

• Status: Completed
• Trial end date: 2005-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary aim of this study is to investigate the effects of oral and inhaled administration of L-arginine and of inhaled aminoguanidine on bronchial and alveolar exhaled NO and NO metabolites in exhaled breath condensate, saliva and nasal lavage fluid in normal and asthmatic subjects.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Imperial College London
• Treatments: Pimagedine

Criteria

Inclusion Criteria:

Healthy non-smokers (n=10):

• Nonatopic subjects (exhaled NO greater than or equal to 10 ppb; flow 50 ml/s)

• Normal spirometry

• Able to comprehend and grant a written informed consent

Asthmatic subjects (n=15):

• Forced expiratory volume in one second (FEV1) of no less than 70% of predicted (exhaled NO greater than or equal to 15 ppb; flow 50 ml/s)

• Clinically stable (steroid-naïve or taking no > 600 mcg/day of inhaled steroids)

• Able to comprehend and grant a written informed consent

Exclusion Criteria:

• Currently smoking

• Any lung disease other than asthma which may interfere with the study

• Treatment within the last 4 weeks with oral steroids

• Respiratory infection within 4 weeks prior to entry into the trial

• Females who are pregnant or lactating

• History of current or past drug or alcohol abuse