Overview

Nitric Oxide-mediated Cardioprotection During Cardiac Surgery With Cardiopulmonary Bypass

Status:
Completed
Trial end date:
2016-11-30
Target enrollment:
0
Participant gender:
All
Summary
This prospective randomized study elucidates the effects of exogenous nitric oxide delivered to the extracorporeal circulation circuit for cardioprotection against ischemia-reperfusion injury during coronary artery bypass graft surgery with cardiopulmonary bypass.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Tomsk National Research Medical Center of the Russian Academy of Sciences
Treatments:
Nitric Oxide
Criteria
Inclusion Criteria:

- Coronary artery disease requiring coronary artery bypass grafting with the
cardiopulmonary bypass.

Exclusion Criteria:

- Non-elective surgery, age over 70 years, left ventricular ejection fraction less than
35%, history of myocardial infarction within three months prior to surgery, chronic
atrial fibrillation, diabetes mellitus, and the elevated levels of cardiac specific
markers within 12 h prior to the intervention.